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Am J Clin Nutr. 2013 Sep;98(3):778-86. doi: 10.3945/ajcn.112.053835. Epub 2013 Jul 10.

Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies.

Author information

1
Department of Histology and Embryology, School of Basic Sciences, Guangzhou Medical University, Guangzhou, China.

Abstract

BACKGROUND:

Observational studies have been inconsistent regarding the association between blood antioxidants or vitamins and risk of age-related cataract.

OBJECTIVE:

We performed a meta-analysis to determine whether an association exists between blood levels of antioxidants or vitamins and age-related cataract in observational studies.

DESIGN:

We searched PubMed, EMBASE, and the Web of Science for relevant studies from inception to October 2012. Study-specific risk estimates were combined by using a random-effects model.

RESULTS:

A total of 13 studies with 18,999 participants were involved in this meta-analysis. A pooled estimate showed vitamin E (OR: 0.75; 95% CI: 0.58, 0.96), α-carotene (OR: 0.72; 95% CI: 0.59, 0.88), lutein (OR: 0.75; 95% CI: 0.65, 0.87), and zeaxanthin (OR: 0.70; 95% CI: 0.60, 0.82) were inversely associated with age-related cataract. Vitamins A (OR: 0.69; 95% CI: 0.58, 0.83) and C (OR: 0.67; 95% CI: 0.57, 0.78) were inversely associated with age-related cataract in Asian populations but not in Western populations. β-Carotene (OR: 0.90; 95% CI: 0.78, 1.05), lycopene (OR: 0.86; 95% CI: 0.65, 1.15), and β-cryptoxanthin (OR: 0.83; 95% CI: 0.68, 1.02) had no significant association with risk of cataract.

CONCLUSIONS:

This meta-analysis provides additional evidence supporting the view that blood levels of certain antioxidants are inversely associated with risk of age-related cataract. However, the role of antioxidant or vitamin supplement intake in preventing cataract should be further investigated in interventional studies.

PMID:
23842458
DOI:
10.3945/ajcn.112.053835
[Indexed for MEDLINE]

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