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Appl Opt. 2013 Jul 1;52(19):4755-62. doi: 10.1364/AO.52.004755.

Pulsed ultrasound modulated optical tomography utilizing the harmonic response of lock-in detection.

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Electrical Systems and Optics Research Division, Faculty of Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.


Ultrasound modulated optical tomography (USMOT) can image the optical properties of a scattering medium at a spatial resolution approaching that of ultrasound (US). A lock-in parallel speckle detection technique is proposed to detect pulsed US modulated light using a multipixel detector. The frequency components of the pass band match those of the US pulse train and provide efficient detection. The modulation depth is extracted by taking the difference between a pair of speckle patterns modulated by a pair of phase-inversed US bursts. Modification to pulse inversion mode enables the second harmonic US modulation due to nonlinear US propagation to be detected.

[Indexed for MEDLINE]

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