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AIDS. 2013 Aug 24;27(13):2163-6. doi: 10.1097/QAD.0b013e3283629095.

Evaluation of an empiric risk screening score to identify acute and early HIV-1 infection among MSM in Coastal Kenya.

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aCentre for Geographic Medicine Research - Coast, Kenya Medical Research Institute - Kilifi, Kilifi, Kenya bNuffield Department of Clinical Medicine, University of Oxford, Headington, UK cInternational AIDS Vaccine Initiative, New York dUniversity of Washington, Seattle, Washington, USA.


We evaluated the University of North Carolina-Malawi Risk Screening Score (UMRSS) for detection of acute and early HIV-1 infection (AEHI) in a cohort of Kenyan MSM with approximately 8% annual HIV-1 incidence. Three components of the UMRSS (fever, diarrhea, and discordant rapid HIV tests) were also independent predictors of AEHI in our cohort. The predictive ability (area under the receiver operating characteristic curve, AUC) of the UMRSS was 0.79. A cohort-derived risk score consisting of six characteristics (fever, diarrhea, discordant rapid HIV tests, fatigue, age <30 years, and symptomatic sexually transmitted disease) had a higher AUC of 0.85. Screening for AEHI will have substantial transmission prevention benefits.

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