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CPT Pharmacometrics Syst Pharmacol. 2013 Jul 10;2:e54. doi: 10.1038/psp.2013.30.

The impact of mathematical modeling on the understanding of diabetes and related complications.

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1] BioModels Group, EMBL - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] Multidiscipinary Centre for Integrative Biology (MyCIB), School of Biosciences, University of Nottingham, Loughborough, UK.


Diabetes is a chronic and complex multifactorial disease caused by persistent hyperglycemia and for which underlying pathogenesis is still not completely understood. The mathematical modeling of glucose homeostasis, diabetic condition, and its associated complications is rapidly growing and provides new insights into the underlying mechanisms involved. Here, we discuss contributions to the diabetes modeling field over the past five decades, highlighting the areas where more focused research is required.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e54; doi:10.1038/psp.2013.30; advance online publication 10 July 2013.

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