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FEBS Lett. 1990 Jul 30;268(1):206-8.

Degradation of type I and II collagen by human activated C1-s.

Author information

1
Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.

Abstract

The activated first component of human complement, C1-s, was shown to cleave type I and II collagen and gelatin. The proteolytic activity was heat labile and was inhibited by a monoclonal antibody (M241) which recognized light chain of active human C1-s or by a serine protease inhibitor, DFP, but not by a chelating agent.

PMID:
2384156
DOI:
10.1016/0014-5793(90)81009-d
[Indexed for MEDLINE]
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