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Int J Inflam. 2013;2013:601424. doi: 10.1155/2013/601424. Epub 2013 Jun 6.

Metabolic acidosis treatment as part of a strategy to curb inflammation.

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1
Department of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-São Paulo 900, 14015-120 Ribeirão Preto, SP, Brazil.

Abstract

Abnormalities in systemic acid-base balance may induce significant changes in the immune response, and they may play a significant role in the development or maintenance of immune dysfunction. Different forms of acidosis (metabolic and respiratory) and even different types of metabolic acidosis (hyperchloremic and lactic) may produce different effects on immune function. If alkalization has, or not, some effect on inflammation control is still a matter of speculation. Studies concerning these subjects are limited justifying this paper.

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