Format

Send to

Choose Destination
Nat Rev Neurosci. 2013 Aug;14(8):536-50. doi: 10.1038/nrn3486. Epub 2013 Jul 10.

Molecular mechanisms of dendrite stability.

Author information

1
Departments of Molecular Biophysics and Biochemistry and Neurobiology, Yale University, 333 Cedar Street SHMC-E31, New Haven, Connecticut 06520-8024, USA. anthony.koleske@yale.edu

Abstract

In the developing brain, dendrite branches and dendritic spines form and turn over dynamically. By contrast, most dendrite arbors and dendritic spines in the adult brain are stable for months, years and possibly even decades. Emerging evidence reveals that dendritic spine and dendrite arbor stability have crucial roles in the correct functioning of the adult brain and that loss of stability is associated with psychiatric disorders and neurodegenerative diseases. Recent findings have provided insights into the molecular mechanisms that underlie long-term dendrite stabilization, how these mechanisms differ from those used to mediate structural plasticity and how they are disrupted in disease.

PMID:
23839597
PMCID:
PMC3947514
DOI:
10.1038/nrn3486
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center