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Nanoscale. 2013 Sep 21;5(18):8288-306. doi: 10.1039/c3nr01630g.

Nanostructure-induced DNA condensation.

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1
National Center for Nanoscience and Technology (NCNST), Beijing 100190, PR China.

Abstract

The control of the DNA condensation process is essential for compaction of DNA in chromatin, as well as for biological applications such as nonviral gene therapy. This review endeavours to reflect the progress of investigations on DNA condensation effects of nanostructure-based condensing agents (such as nanoparticles, nanotubes, cationic polymer and peptide agents) observed by using atomic force microscopy (AFM) and other techniques. The environmental effects on structural characteristics of nanostructure-induced DNA condensates are also discussed.

PMID:
23838744
DOI:
10.1039/c3nr01630g
[Indexed for MEDLINE]
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