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J Complement Integr Med. 2013 Jul 6;10. pii: /j/jcim.2013.10.issue-1/jcim-2013-0008/jcim-2013-0008.xml. doi: 10.1515/jcim-2013-0008.

Antidiabetic and antihypertensive effect of Virgin Argan Oil in model of neonatal streptozotocin-induced diabetic and l-nitroarginine methylester (l-NAME) hypertensive rats.

Author information

1
Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco. bellahcen_said@yahoo.fr

Abstract

BACKGROUND:

The goal of this study was to examine the effect of Virgin Argan Oil (VAO) obtained from the fruit of Argania spinosa in a model of type 2 diabetes and hypertensive rats. Neonatal diabetes was induced by a single i.p. injection of streptozotocin (90 mg/kg) 2 days after birth. To induce NO-deficient hypertension, the adult diabetic animals were treated with l-nitroarginine methylester (l-NAME) (30 mg/kg/day) given orally for 21 days.

METHODS:

Following treatment with VAO (21 days), the hyperglycemia decreased to 1.3 ± 0.07 g/l compared with 1.92 ± 0.09 g/l (p < 0.01) in the untreated diabetic-hypertensive rats. The simultaneous administration of VAO with l-NAME prevented the increase in blood pressure during the 3 weeks of treatment. Blood pressure remained constant at 131 ± 1 mm Hg after 21 days - vs 157 ± 0.64 mm Hg in untreated animals (p < 0.001).

RESULTS:

The treatment with VAO to diabetic-hypertensive rats caused a significant increase of hepatic glycogen levels (13.3 ± 1.8 vs 6.34 ± 0.75 mg/g tissue in untreated diabetic-hypertensive control group; p < 0.01).

CONCLUSIONS:

In conclusion, the overall findings indicate that VAO possesses antidiabetic and antihypertensive activity in n-stz/l-NAME rats. This effect may be related to its high content of tocopherols, phenolic compounds, and unsaturated fatty acids.

PMID:
23836726
DOI:
10.1515/jcim-2013-0008
[Indexed for MEDLINE]

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