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Adv Mater. 2013 Sep 14;25(34):4714-7. doi: 10.1002/adma.201301175. Epub 2013 Jul 9.

A triggered DNA hydrogel cover to envelop and release single cells.

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Key Laboratory of Organic Optoelectrics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China, Fax: +86-10-62796082; National Center for Nanoscience and Technology, Beijing 100190, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China.


We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication.


DNA hydrogel; envelop and release; permeable; responsiveness; single cell

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