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Magn Reson Med. 2014 May;71(5):1784-97. doi: 10.1002/mrm.24843. Epub 2013 Jul 8.

Myocardial perfusion quantification using the T1 -based FAIR-ASL method: the influence of heart anatomy, cardiopulmonary blood flow and look-locker readout.

Author information

1
Universität Würzburg, Lehrstuhl für Experimentelle Physik 5, Am Hubland, Würzburg, Germany.

Abstract

PURPOSE:

The quantification of myocardial perfusion using a Look-Locker flow-sensitive alternating inversion recovery- arterial spin labeling experiment is considered. Due to the anatomy of the heart, a substantial but unintended partial inversion of the inflowing blood occurs during the slice-selective inversion. Both, the partial inversion as well as the Look-Locker pulse train, influence the myocardial perfusion quantification and are addressed in this work.

METHODS:

The mean relaxation time approximation is used to calculate the monoexponential relaxation time of the signal in perfused tissue under Look-Locker readout. The left ventricular blood serves as an approximation of the inflowing blood in the description of FAIR-ASL measurements with global and slice-selective inversion to correctly quantify the myocardial perfusion.

RESULTS:

The analysis shows that the myocardial perfusion can be overestimated if the T1 -based quantification method is not adapted respecting the Look-Locker pulse train explicitly. Additionally, it turns out that without correction for the partial inversion of the blood pool during the slice-selective inversion the myocardial perfusion is underestimated.

CONCLUSION:

It is shown that the Look-Locker readout as well as the nonideal slice-selective inversion experiment have a considerable influence and have to be included properly to correctly quantify myocardial perfusion.

KEYWORDS:

Look-Locker; anatomy; arterial spin labeling; cardiac; cardiopulmonary blood flow; perfusion; regional blood volume

PMID:
23836533
DOI:
10.1002/mrm.24843
[Indexed for MEDLINE]
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