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Br J Clin Pharmacol. 2014 Apr;77(4):618-25. doi: 10.1111/bcp.12208.

The genetics of pro-arrhythmic adverse drug reactions.

Author information

1
Human Genetics Research Centre, Division of Biomedical Sciences, St George's Hospital Medical School, London, SW17 0RE, UK.

Abstract

Ventricular arrhythmia induced by drugs (pro-arrythmia) is an uncommon event, whose occurrence is unpredictable but potentially fatal. The ability of a variety of medications to induce these arrhythmias is a significant problem facing the pharmaceutical industry. Genetic variants have been shown to play a role in adverse events and are also known to influence an individual's optimal drug dose. This review provides an overview of the current understanding of the role of genetic variants in modulating the risk of drug induced arrhythmias.

KEYWORDS:

QT interval; adverse drug reactions; genetics; genomics; long QT syndrome; pro-arrhythmia

PMID:
23834499
PMCID:
PMC3971979
DOI:
10.1111/bcp.12208
[Indexed for MEDLINE]
Free PMC Article

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