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Indian J Pharmacol. 2013 May-Jun;45(3):217-22. doi: 10.4103/0253-7613.111894.

Effect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: a randomized, placebo-controlled, double-blind clinical trial.

Author information

1
Departamento de Nutrição Clínica- University of Brasilia-DF, Brazil.

Abstract

BACKGROUND:

Breast cancer (BC) represents the highest incidence of malignancy in women throughout the world. Medicinal fungi can stimulate the body, reduce side-effects associated with chemotherapy and improve the quality of life in patients with cancer.

AIM:

To evaluate the effects of dietary supplementation of Agaricus sylvaticus on clinical and nutritional parameters in BC patients undergoing chemotherapy.

MATERIALS AND METHODS:

A randomized, placebo-controlled, double-blind, clinical trial was carried out at the Oncology Clinic, Hospital of the Federal District-Brazil from September 2007 to July 2009. Forty six patients with BC, Stage II and III, were randomly assigned to receive either nutritional supplement with A. sylvaticus (2.1 g/day) or placebo. Patients were evaluated during treatment period.

RESULTS:

Patient supplemented with A. sylvaticus improved in clinical parameters and gastrointestinal functions. Poor appetite decreased by 20% with no changes in bowel functions (92.8%), nausea and vomiting (80%).

CONCLUSION:

Dietary supplementation with A. sylvaticus improved nutritional status and reduced abnormal bowel functions, nausea, vomiting, and anorexia in patients with BC receiving chemotherapy.

KEYWORDS:

Agaricus sylvaticus; chemotherapy side effects; nutritional status

PMID:
23833361
PMCID:
PMC3696289
DOI:
10.4103/0253-7613.111894
[Indexed for MEDLINE]
Free PMC Article

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