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Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. Epub 2013 Jul 5.

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.

Author information

1
School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia.

Abstract

The heterologous expression of microbial natural product biosynthetic pathways coupled with advanced DNA engineering enables optimisation of product yields, functional elucidation of cryptic gene clusters, and generation of novel derivatives. This review summarises the recent advances in cloning and maintenance of natural product biosynthetic gene clusters for heterologous expression and the efforts fundamental for discovering novel natural products in the post-genomics era, with a focus on polyketide synthases (PKSs) and non-ribosomal polypeptide synthetases (NRPS).

PMID:
23832108
DOI:
10.1039/c3np70034h
[Indexed for MEDLINE]

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