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Bull Cancer. 2013 Jul-Aug;100(7-8):757-64. doi: 10.1684/bdc.2013.1785.

[The Fallopian tube odyssey: from the ovary to the tube. About high-grade serous ovarian carcinoma].

[Article in French]

Author information

1
Centre Jean-Perrin, Département d'Anatomie et de Cytologie Pathologiques, 58 rue Montalembert, 63000 Clermont-Ferrand, France. chenegautier@yahoo.fr

Abstract

Ovarian serous carcinoma is the most threatening type of gynaecological cancer because of late diagnosis at the advanced stage of peritoneal carcinomatosis stage. Identification of precancerous lesions could be essential in our understanding of ovarian carcinogenesis and might allow the development of effective screening tools. A serous carcinogenic sequence has been recently described in the Fallopian tube whereas an ovarian preinvasive lesion--ovarian epithelial dysplasia--was previously found. In light of recent and past molecular studies, we will review and discuss these two theories.

KEYWORDS:

Fallopian tube; STIC; ovarian cancer; ovarian carcinogenesis; ovarian dysplasia; p53

PMID:
23831931
DOI:
10.1684/bdc.2013.1785
[Indexed for MEDLINE]
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