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Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:78-85. doi: 10.1016/j.pnpbp.2013.06.015. Epub 2013 Jul 4.

Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies.

Author information

1
Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan road, Hefei, Anhui 230032, China.

Abstract

BACKGROUND:

Previous studies concerning the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and depression have provided inconclusive findings. A meta-analysis was therefore performed to investigate a more reliable estimate.

METHODS:

This meta-analysis recruited 26 published studies which were selected by a search of electronic databases up to January 2013, including 4992 depression cases and 17,082 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR C677T polymorphism and depression susceptibility using random effect models.

RESULTS:

Meta-analyses results suggested that MTHFR C677T polymorphism contributed to the increased depression risk in overall populations (for T vs. C: OR=1.19, 95%CI=1.07-1.32; for TT+CT vs. CC: OR=1.15, 95%CI=1.01-1.31; for TT vs. CC: OR=1.42, 95%CI=1.16-1.75; for TT vs. CT+CC: OR=1.38, 95%CI=1.16-1.63). Subgroup analysis by ethnicity indicated an association in Asian populations (for T vs. C: OR=1.36, 95%CI=1.11-1.66; for TT+CT vs. CC: OR=1.32, 95%CI=1.03-1.69; for TT vs. CC: OR=1.88, 95%CI=1.26-2.79; for TT vs. CT+CC: OR=1.76, 95%CI=1.30-2.38); and a marginal association in White populations (for TT vs. CT+CC: OR=1.15, 95%CI=1.01-1.31). However, the association between the MTHFR C677T polymorphism and depression was not observed in the elderly.

CONCLUSION:

The MTHFR C677T polymorphism was associated with an increased risk of depression, especially in Asian populations. However, there was no evidence indicating a correlation in the elderly.

KEYWORDS:

5,10-methylenetetrahydrofolate reductase; CIs; Depression; HWE; Hardy–Weinberg equilibrium; MTHFR; Meta-analysis; Methylenetetrahydrofolate reductase; ORs; Odds ratios; Polymorphism; confidence intervals

PMID:
23831680
DOI:
10.1016/j.pnpbp.2013.06.015
[Indexed for MEDLINE]

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