Format

Send to

Choose Destination
Biochim Biophys Acta. 2014 Apr;1838(4):1074-81. doi: 10.1016/j.bbamem.2013.06.029. Epub 2013 Jul 3.

HIV-1 Vpu - an ion channel in search of a job.

Author information

1
Viral Biochemistry Section, Laboratory of Molecular Microbiology, NIAID, NIH Bldg. 4, Room 310, 4 Center Drive MSC 0460, Bethesda, MD 20892-0460, USA. Electronic address: kstrebel@nih.gov.

Abstract

Vpu is a small membrane protein encoded by HIV-1 and some SIV isolates. The protein is best known for its ability to degrade CD4 and to enhance the release of progeny virions from infected cells. However, Vpu also promotes host-cell apoptosis by deregulating the NFκB signaling pathway and it assembles into cation-conducting membrane pores. This review summarizes our current understanding of these various functions of Vpu with particular emphasis on recent progress in the Vpu field. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.

KEYWORDS:

BST-2; CD4; HIV-1; Ion channel; Tetherin; Vpu

PMID:
23831603
PMCID:
PMC3859730
DOI:
10.1016/j.bbamem.2013.06.029
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center