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Sleep Med. 2013 Sep;14(9):838-42. doi: 10.1016/j.sleep.2013.05.002. Epub 2013 Jul 3.

Association between severe obstructive sleep apnea and incident arterial hypertension in the older people population.

Author information

1
Jean Monnet University, Saint-Etienne, France.

Abstract

OBJECTIVES:

The impact of sleep-related breathing disorders on the incidence of arterial hypertension (AHT) in the older adults is not well-established. The aim of our study was to test the link between severe obstructive sleep apnea (OSA) and the occurrence of hypertension in older subjects after 3 years.

METHODS:

372 normotensive subjects with a mean age of 68.2 years were included in our longitudinal study. All participants had a ventilatory polygraphic recording and an ambulatory blood pressure (BP) monitoring at baseline and after 3 years. Severe OSA was defined by an apnea-hypopnea index (AHI) of ≥ P30 per hour. A new onset of hypertension was defined according to a mean 24-hour value >140mmHg for systolic BP and >85mmHg for diastolic BP or the use of antihypertensive medication.

RESULTS:

The baseline factors significantly associated with an increased risk for new-onset hypertension were male gender, obesity, diabetes mellitus (DM), dyslipidemia, and OSA. Multiple logistic regression analyses showed that an AHI ≥30 per hour was independently associated with incident hypertension after 3 years (P=.02; odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-2.8).

CONCLUSIONS:

The presence of severe OSA is associated with new-onset AHT in normotensive elderly (mean age, 68.2 y) subjects.

KEYWORDS:

Ambulatory blood pressure monitoring; Elderly; Epidemiology; Hypertension; Obstructive sleep apnea; Sleep related breathing disorders

PMID:
23831239
DOI:
10.1016/j.sleep.2013.05.002
[Indexed for MEDLINE]

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