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Fertil Steril. 2013 Nov;100(5):1358-63. doi: 10.1016/j.fertnstert.2013.06.027. Epub 2013 Jul 3.

Clinical pregnancy after uterus transplantation.

Author information

1
Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey. Electronic address: meakar@akdeniz.edu.tr.

Abstract

OBJECTIVE:

To present the first clinical pregnancy after uterus transplantation.

DESIGN:

Case study.

SETTING:

Tertiary center.

PATIENT(S):

A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.

INTERVENTION(S):

Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.

MAIN OUTCOME MEASURE(S):

Implantation of embryo in an allografted human uterus.

RESULT(S):

The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.

CONCLUSION(S):

We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.

KEYWORDS:

Uterus transplantation; clinical pregnancy; uterine factor infertility

[Indexed for MEDLINE]

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