Send to

Choose Destination
Handb Clin Neurol. 2013;114:183-91. doi: 10.1016/B978-0-444-53490-3.00012-1.


Author information

Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.


Microsporidia are obligate intracellular spore-forming organisms. Several species of microsporidia cause human disease, mainly in immunocompromised hosts. The spectrum of disease varies from diarrhea, keratoconjunctivitis to disseminated infection involving multiple organs. CNS disease is a rare manifestation usually seen in compromised hosts as part of a disseminated infection. Only 12 cases of CNS microsporidiosis have been reported in the literature. Clinically, they usually present with signs and symptoms of encephalitis and seizures. Diagnosis often requires brain biopsy, but spores can occasionally be found in other sites. Albendazole and fumagillin have been successfully used in treating microsporidiosis at other sites, but their role in CNS infection is unclear.


Microsporidiosis; encephalitozoon; fumagillin

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center