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J Altern Complement Med. 2013 Nov;19(11):905-10. doi: 10.1089/acm.2012.0914. Epub 2013 Jul 5.

Effect of active hexose-correlated compound in women receiving adjuvant chemotherapy for breast cancer: a retrospective study.

Author information

1
1 Department of Hematology and Oncology, The University of Tokyo Hospital , Bunkyo-ku, Tokyo, Japan .

Abstract

OBJECTIVES:

Anthracyclines and taxanes are often used as first-line chemotherapy treatments in patients with breast cancer. There are, however, significant toxicity and side effects associated with these therapies. Previous studies have demonstrated that active hexose-correlated compound (AHCC) reduces such side effects. The present study explored the beneficial effects of AHCC on adverse events in patients receiving adjuvant chemotherapy for breast cancer.

SUBJECTS:

Forty-one women who were treated with anthracyclines and taxanes at Nagumo Clinic in Tokyo from October 2004 to March 2011 were selected for this study.

OUTCOME MEASURES:

We compared the occurrence of adverse events in patients who received AHCC with those who did not receive AHCC. Using Fisher's exact tests, we also compared the worst-grade adverse events in each treatment cycle. Generalized estimating equations were employed to compare longitudinal changes, and the use of granulocyte colony-stimulating factor, in the two groups was analyzed using Student's t-test.

RESULTS:

We found that, compared to the control group, the AHCC group had significantly fewer neutrophil-related events (odds ratio, 0.30; p=0.016), significantly lower use of granulocyte colony-stimulating factor, and a higher (although not significant) rate of adverse events associated with γ-glutamyl transpeptidase.

CONCLUSIONS:

AHCC has the potential to reduce the severity of neutropenia induced by breast cancer chemotherapy and the use of G-CSF during chemotherapy.

PMID:
23829813
PMCID:
PMC3842887
DOI:
10.1089/acm.2012.0914
[Indexed for MEDLINE]
Free PMC Article

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