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Adv Clin Exp Med. 2013 May-Jun;22(3):369-75.

An analysis of the impact of clinico-pathological features on long-term results following esophagectomy due to squamous cell carcinoma of the thoracic esophagus.

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1
Department and Clinic of Gastrointestinal and General Surgery , Wrocław Medical University, Poland.

Abstract

BACKGROUND:

Squamous cell carcinoma of the esophagus is one of the neoplasms characterized by an exceptionally latent course, dynamic development and poor prognosis. The stage of the disease at the time of treatment is started the greatest impact on the long term results.

OBJECTIVES:

The aim of this study was to evaluate selected clinical-pathological features as prognostic factors for long term survival among patients who have undergone esophagectomies due to squamous cell carcinoma. The features analyzed were age, gender, the stage of the disease and the type of tumor. Long-term survival rates (2, 5 and 10 years) were analyzed in relation to the particular features.

MATERIAL AND METHODS:

The study group consisted of 65 patients diagnosed with squamous cell carcinoma of the thoracic esophagus who underwent esophagectomies between 1997 and 2008. The statistical analysis was performed with Statistca 8.0 software. Gehan-Wilcoxon, chi and Kaplan-Meier tests were carried out.

RESULTS:

The research did not find any statistically significant correlation between the patients' gender and survival time (Gehan-Wilcoxon p = 0.83; log-rank p = 0.86). The results showed no statistically significant correlation between the patients' age and survival time (Gehan-Wilcoxon p = 0.75; log-rank p = 0.47). The only statistically significant impact of the stage of the disease on the survival time was a correlation between the longer survival time and the stage I and II of the disease (Chi p = 0.15). The log-rank test revealed that survival time is significantly shorter in cases of involved nodes (Gehan-Wilcoxon p = 0.054; log-rank p = 0.014).

CONCLUSIONS:

Among the clinical-pathological features investigated, only metastases in regional lymph nodes had any significant impact on long-term survival.

PMID:
23828678
[Indexed for MEDLINE]
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