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Cell Death Dis. 2013 Jul 4;4:e703. doi: 10.1038/cddis.2013.218.

The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity.

Author information

1
Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA.

Abstract

In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences such as cancers and mental retardation. Here we demonstrate that deletion of a G-protein-coupled purinergic receptor, P2Y14, confers potent resistance to in utero radiation. Intriguingly, a putative P2Y14 receptor ligand, UDP-glucose, phenocopies the effect of P2Y14 deficiency. These data indicate that P2Y14 is a receptor governing in utero tolerance to genotoxic stress that may be pharmacologically targeted to mitigate radiation toxicity in pregnancy.

PMID:
23828566
PMCID:
PMC3730399
DOI:
10.1038/cddis.2013.218
[Indexed for MEDLINE]
Free PMC Article

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