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Nat Rev Immunol. 2013 Aug;13(8):607-14. doi: 10.1038/nri3476. Epub 2013 Jul 5.

Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

Author information

1
Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, State University of New Jersey, Newark, New Jersey 07103-2757, USA.

Abstract

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

PMID:
23827958
PMCID:
PMC3789590
DOI:
10.1038/nri3476
[Indexed for MEDLINE]
Free PMC Article

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