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J Am Med Dir Assoc. 2013 Sep;14(9):690-5. doi: 10.1016/j.jamda.2013.05.017. Epub 2013 Jul 1.

Agitation in nursing home residents with dementia (VIDEANT trial): effects of a cluster-randomized, controlled, guideline implementation trial.

Author information

1
Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Berlin, Germany; Social and Preventive Medicine, Department of Health and Sports Sciences, University of Potsdam, Potsdam, Germany. Electronic address: michael.rapp@uni-potsdam.de.

Abstract

OBJECTIVE:

To test the effect of a complex guideline-based intervention on agitation and psychotropic prescriptions.

DESIGN, SETTING, PARTICIPANTS:

Cluster randomized controlled trial (VIDEANT) with blinded assessment of outcome in 18 nursing homes in Berlin, Germany, comprising 304 dementia patients.

INTERVENTION:

Training, support, and activity therapy intervention, delivered at the level of each nursing home, focusing on the management of agitation in dementia. Control group nursing homes received treatment as usual.

MEASUREMENTS:

Levels of agitated and disruptive behavior (Cohen-Mansfield agitation inventory [CMAI]) as the primary outcome. Number of neuroleptics, antidepressants, and cholinesterase inhibitors (ChEIs) prescribed in defined daily dosages (DDDs).

RESULTS:

Of 326 patients screened, 304 (93.3%) were eligible and cluster-randomized to 9 intervention (n = 163) and 9 control (n = 141) nursing homes. Data were collected from 287 (94.4%) patients at 10 months. At 10 months, compared with controls, nursing home residents with dementia in the intervention group exhibited significantly less agitation as measured with the CMAI (adjusted mean difference, 6.24; 95% CI 2.03-14.14; P = .009; Cohen's d = 0.43), received fewer neuroleptics (P < .05), more ChEIs (P < .05), and more antidepressants (P < .05).

CONCLUSION:

Complex guideline-based interventions are effective in reducing agitated and disruptive behavior in nursing home residents with dementia. At the same time, increased prescription of ChEIs and antidepressants together with decreased neuroleptic prescription suggests an effect toward guideline-based pharmacotherapy.

KEYWORDS:

Dementia; agitation; guideline; nursing home; trial

PMID:
23827658
DOI:
10.1016/j.jamda.2013.05.017
[Indexed for MEDLINE]
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