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Mater Sci Eng C Mater Biol Appl. 2013 Apr 1;33(3):1300-6. doi: 10.1016/j.msec.2012.12.029. Epub 2012 Dec 13.

Preparation of grafted microspheres CPVA-g-PSSS and studies on their drug-carrying and colon-specific drug delivery properties.

Author information

1
Department of Chemical Engineering, North University of China, Taiyuan 030051, People' s Republic of China. gaobaojiao@126.com

Abstract

Sodium 4-styrene sulfonate (SSS) was graft-polymerized on the surfaces of crosslinked polyvinyl alcohol (CPVA) microspheres in a manner of surface-initiated graft-polymerization by using cerium salt-hydroxyl group redox initiation system, obtaining the grafted microspheres CPVA-g-PSSS. The chemical structure and physicochemical characters of CPVA-g-PSSS microspheres were fully characterized with infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and zeta potential determination. The aim of this work is to constitute a novel colon-specific drug delivery system via molecular design by using CPVA-g-PSSS microspheres as the drug-carrying material and by taking metronidazole (MTZ) as the model drug. The drug-carrying ability and mechanism of the grafted microspheres CPVA-g-PSSS for MTZ were investigated. Finally, in-vitro release tests for the drug-carrying microspheres were conducted. The experimental results show that in an acidic medium, the grafted microspheres CPVA-g-PSSS exhibit strong adsorption ability for MTZ by driving of electrostatic interaction, and have an adsorption capacity of 112 mg/g, displaying the high efficiency of drug-carrying. The in-vitro release behavior of the drug-carried microspheres is highly pH-sensitive. In the medium of pH=1, the drug-carrying microspheres do not release the drug, whereas in the medium of pH=7.4, a sudden delivery phenomenon of the drug will occur, displaying an excellent colon-specific drug delivery behavior.

KEYWORDS:

Colon-specific drug delivery; Crosslinked polyvinyl alcohol; Dependence of pH; Graft polymerization; Metronidazole; Sodium 4-styrene sulfonate

PMID:
23827575
DOI:
10.1016/j.msec.2012.12.029
[Indexed for MEDLINE]
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