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Gene. 2013 Sep 15;527(1):311-5. doi: 10.1016/j.gene.2013.06.031. Epub 2013 Jul 1.

Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis.

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1
Department of Ophthalmology, Jinling Hospital, Nanjing University, PR China.

Abstract

BACKGROUND:

Glutathione S-transferase (GST) variants have been considered as risk factors for the pathogenesis of primary open angle glaucoma (POAG). However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association between GSTM1 and GSTT1 null genotypes and the risk for POAG.

METHODS:

Published literature from PubMed and EMBASE databases was retrieved. All studies evaluating the association between GSTM1/GSTT1 variants and POAG were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed- or random-effects model.

RESULTS:

14 studies (1711 POAG cases and 1537 controls) were included in the meta-analysis of GSTM1 genotypes and 10 studies (1306 POAG cases and 1114 controls) were included in the meta-analysis of GSTT1 genotypes. The overall result showed that the association between GSTM1 and GSTT1 null genotypes and risk for POAG was not statistically significant (GSTM1: OR=1.19, 95% CI=0.82-1.73, p=0.361; GSTT1: OR=1.26, 95% CI=0.77-2.06, p=0.365). The results by ethnicity showed that the association between the GSTM1 null genotype and risk for POAG is statistically significant in East Asians (OR=1.41, 95% CI=1.04-1.90, p=0.026), but not in Caucasians (OR=1.13, 95% CI=0.69-1.84, p=0.638) and Latin-American (OR=1.09, 95% CI=0.62-1.92, p=0.767). In addition, there was no significant association of GSTT1 null genotype with risk for POAG in either ethnic population.

CONCLUSIONS:

The present meta-analysis suggested that there might be a significant association of GSTM1 null genotype with POAG risk in East Asians.

KEYWORDS:

CI; GST; GSTM1; GSTT1; OR; POAG; Primary open-angle glaucoma; Variant; confidence interval; glutathione S-transferase; odds ratio; primary open angle glaucoma

PMID:
23827458
DOI:
10.1016/j.gene.2013.06.031
[Indexed for MEDLINE]
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