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Zhonghua Xue Ye Xue Za Zhi. 2013 Jun;34(6):498-501. doi: 10.3760/cma.j.issn.0253-2727.2013.06.007.

[The retrospective study of serum aspergillus galactomannan (GM) antigen assay in invasive aspergillosis on hematological diseases].

[Article in Chinese]

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1
Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, China.

Abstract

OBJECTIVE:

To explore the relationship between the optical density index of serum aspergillus galactomannan (GM) assay and invasive aspergillosis (IA).

METHODS:

From Jan 2008 to Dec 2011, 825 hematological diseases patients with neutrophil count <0.5×10⁹/L⁹ by continuous blood count tests were admitted into our hospital. The optical density index of GM assay was ≥0.5 at least once. Of 825 patients, 247 cases were manifested as fever during hospitalization. The optical density index of GM antigen was detected by enzyme-linked immunosorbent assay, and the sensitivity and specificity of optical density ranged in 0.5-1.5.

RESULTS:

In this study, the sensitivity and specificity of GM assay with continuous twice samples (73% and 93%, respectively) were higher than single sample (66% and 80%, respectively) when optical density index ≥1.0. 69 cases were diagnosed as proven IA with the incidence rate of 8.36%.

CONCLUSION:

The cut-off level for serum GM antigen assay should be decided as optical density index in two continuous samples of ≥1.0.

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