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PLoS One. 2013 Jun 24;8(6):e67479. doi: 10.1371/journal.pone.0067479. Print 2013.

Two ENU-induced alleles of Atp2b2 cause deafness in mice.

Author information

1
Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia. marina.carpinelli@mcri.edu.au

Erratum in

  • PLoS One. 2013;8(7). doi:10.1371/annotation/f605bb2c-37b6-4fa7-a213-324df679c464. Rachel, A Burt [corrected to Burt, Rachel A].

Abstract

Over 120 loci are known to cause inherited hearing loss in humans. The deafness gene has been identified for only half of these loci. With the aim of identifying some of the remaining deafness genes, we performed an ethylnitrosourea mutagenesis screen for deaf mice. We isolated two mutants with semi-dominant hearing loss, Deaf11 and Deaf13. Both contained causative mutations in Atp2b2, which encodes the plasma membrane calcium ATPase 2. The Atp2b2 (Deaf11) mutation leads to a p. I1023S substitution in the tenth transmembrane domain. The Atp2b2 (Deaf13) mutation leads to a p. R561S substitution in the catalytic core. Mice homozygous for these mutations display profound hearing loss. Heterozygotes display mild to moderate, progressive hearing loss.

PMID:
23826306
PMCID:
PMC3691321
DOI:
10.1371/journal.pone.0067479
[Indexed for MEDLINE]
Free PMC Article

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