Format

Send to

Choose Destination
J Leukoc Biol. 2013 Sep;94(3):409-21. doi: 10.1189/jlb.0413207. Epub 2013 Jul 3.

Location, location, location: tissue-specific regulation of immune responses.

Author information

1
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Abstract

Discovery of DCs and PRRs has contributed immensely to our understanding of induction of innate and adaptive immune responses. Activation of PRRs leads to secretion of inflammatory cytokines that regulate priming and differentiation of antigen-specific T and B lymphocytes. Pathogens enter the body via different routes, and although the same set of PRRs is likely to be activated, it is becoming clear that the route of immune challenge determines the nature of outcome of adaptive immunity. In addition to the signaling events initiated following innate-immune receptor activation, the cells of the immune system are influenced by the microenvironments in which they reside, and this has a direct impact on the resulting immune response. Specifically, immune responses could be influenced by specialized DCs, specific factors secreted by stromal cells, and also, by commensal microbiota present in certain organs. Following microbial detection, the complex interactions among DCs, stromal cells, and tissue-specific factors influence outcome of immune responses. In this review, we summarize recent findings on the phenotypic heterogeneity of innate and adaptive immune cells and how tissue-specific factors in the systemic and mucosal immune system influence the outcome of adaptive-immune responses.

KEYWORDS:

dendritic cell; microbiota; microenvironment

PMID:
23825388
PMCID:
PMC3747123
DOI:
10.1189/jlb.0413207
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center