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Methods Mol Biol. 2013;1015:87-96. doi: 10.1007/978-1-62703-435-7_5.

TaqMan® drug metabolism genotyping assays for the detection of human polymorphisms involved in drug metabolism.

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1
Life Technologies, South San Francisco, CA, USA.

Abstract

Polymorphisms associated with genes that code for various drug-metabolizing enzymes (DMEs) and associated transport proteins can influence the rate of drug metabolism within individuals, thus potentially affecting drug efficacy and the occurrence of side effects. There are 2,700 unique TaqMan(®) Drug Metabolism Genotyping Assays (Life Technologies) for detecting single nucleotide polymorphisms (SNPs), insertions and deletions (indels), and multinucleotide polymorphisms (MNPs) in both coding and regulatory regions. These research assays are useful tools for better understanding genetic variation in drug metabolism. Here we describe the procedure for measuring genetic variation in human DNA using TaqMan(®) Drug Metabolism Genotyping Assays. These assays are for research use only and are not intended for any animal or human therapeutic or diagnostic use.

PMID:
23824850
DOI:
10.1007/978-1-62703-435-7_5
[Indexed for MEDLINE]

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