Format

Send to

Choose Destination
See comment in PubMed Commons below
MAGMA. 2014 Feb;27(1):101-6. doi: 10.1007/s10334-013-0391-6. Epub 2013 Jul 4.

Visualization of immune cell infiltration in experimental viral myocarditis by (19)F MRI in vivo.

Author information

1
Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.

Abstract

OBJECTIVE:

This paper introduces a new approach permitting for the first time a specific, non-invasive diagnosis of myocarditis by visualizing the infiltration of immune cells into the myocardium.

MATERIALS AND METHODS:

The feasibility of this approach is shown in a murine model of viral myocarditis. Our study uses biochemically inert perfluorocarbons (PFCs) known to be taken up by circulating monocytes/macrophages after intravenous injection.

RESULTS:

In vivo (19)F MRI at 9.4 T demonstrated that PFC-loaded immune cells infiltrate into inflamed myocardial areas. Because of the lack of any fluorine background in the body, detected (19)F signals of PFCs are highly specific as confirmed ex vivo by flow cytometry and histology.

CONCLUSION:

Since PFCs are a family of compounds previously used clinically as blood substitutes, the technique described in our paper holds the potential as a new imaging modality for the diagnosis of myocarditis in man.

PMID:
23824166
DOI:
10.1007/s10334-013-0391-6
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center