Format

Send to

Choose Destination
See comment in PubMed Commons below
Toxicol Ind Health. 2015 Dec;31(12):1281-7. doi: 10.1177/0748233713491813. Epub 2013 Jul 3.

Anti-inflammatory activity of Heliotropium strigosum in animal models.

Author information

1
Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan hkdr2006@gmail.com.
2
Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
3
PCSIR Laboratories, Peshawar, Pakistan.
4
Department of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan.
5
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

Abstract

The current project was designed to evaluate the anti-inflammatory activity of crude extract of Heliotropium strigosum and its subsequent solvent fractions in post carrageenan-induced edema and post xylene-induced ear edema at 50, 100, and 200 mg/kg intraperitoneally. The results revealed marked attenuation of edema induced by carrageenan injection in a dose-dependent manner. The ethyl acetate fraction was most dominant with 73.33% inhibition followed by hexane fraction (70.66%). When the extracts were challenged against xylene-induced ear edema, again ethyl acetate and hexane fractions were most impressive with 38.21 and 35.77% inhibition, respectively. It is concluded that various extracts of H. strigosum possessed strong anti-inflammatory activity in animal models.

KEYWORDS:

Heliotropium strigosum; anti-inflammatory; carrageenan; ear edema

PMID:
23823617
DOI:
10.1177/0748233713491813
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center