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Nat Rev Cancer. 2013 Aug;13(8):572-83. doi: 10.1038/nrc3557. Epub 2013 Jul 4.

Serine, glycine and one-carbon units: cancer metabolism in full circle.

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1
Field of Biochemistry and Molecular Cell Biology, Cornell University, Ithaca New York 14850, USA. Locasale@cornell.edu

Abstract

One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins, and generates diverse outputs, such as the biosynthesis of lipids, nucleotides and proteins, the maintenance of redox status and the substrates for methylation reactions. Long considered a 'housekeeping' process, this pathway has recently been shown to have additional complexity. Genetic and functional evidence suggests that hyperactivation of this pathway is a driver of oncogenesis and establishes a link to cellular epigenetic status. Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine.

PMID:
23822983
PMCID:
PMC3806315
DOI:
10.1038/nrc3557
[Indexed for MEDLINE]
Free PMC Article
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