Format

Send to

Choose Destination
See comment in PubMed Commons below
Genetics. 2013 Sep;195(1):221-30. doi: 10.1534/genetics.113.152983. Epub 2013 Jul 2.

Distortions in genealogies due to purifying selection and recombination.

Author information

1
Department of Organismic and Evolutionary Biology, Department of Physics, and Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138.

Abstract

Purifying selection at many linked sites alters patterns of molecular evolution, reducing overall diversity and distorting the shapes of genealogies. Recombination attenuates these effects; however, purifying selection can significantly distort genealogies even for substantial recombination rates. Here, we show that when selection and/or recombination are sufficiently strong, the genealogy at any single site can be described by a time-dependent effective population size, Ne(t), which has a simple analytic form. Our results illustrate how recombination reduces distortions in genealogies and allow us to quantitatively describe the shapes of genealogies in the presence of strong purifying selection and recombination. We also analyze the effects of a distribution of selection coefficients across the genome.

KEYWORDS:

coalescent; genealogies; linkage; purifying selection; recombination

PMID:
23821597
PMCID:
PMC3761303
DOI:
10.1534/genetics.113.152983
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center