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Chemistry. 2013 Aug 5;19(32):10536-42. doi: 10.1002/chem.201301825. Epub 2013 Jul 2.

Synthesis and structural characterization of hexacoordinate silicon, germanium, and titanium complexes of the E. coli siderophore enterobactin.

Author information

1
Technische Universität Berlin, Fakultät II, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.

Abstract

The E. coli siderophore enterobactin, one of the strongest Fe(III) chelators known to date, is also capable of binding Si(IV) under physiological conditions. We report on the synthesis and structural characterization of the tris(catecholate) Si(IV) -enterobactin complex and its Ge(IV) and Ti(IV) analogues. Comparative structural analysis, supported by quantum-chemical calculations, reveals the correlation between the ionic radius and the structural changes in enterobactin upon complexation.

KEYWORDS:

enterobactin; germanium; siderophores; silicon; titanium

PMID:
23821482
DOI:
10.1002/chem.201301825
[Indexed for MEDLINE]

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