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Histochem Cell Biol. 2013 Sep;140(3):361-7. doi: 10.1007/s00418-013-1119-4. Epub 2013 Jul 3.

Golgi as an MTOC: making microtubules for its own good.

Author information

1
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

In cells, microtubules (MTs) are nucleated at MT-organizing centers (MTOCs). The centrosome-based MTOCs organize radial MT arrays, which are often not optimal for polarized trafficking. A recently discovered subset of non-centrosomal MTs nucleated at the Golgi has proven to be indispensable for the Golgi organization, post-Golgi trafficking and cell polarity. Here, we summarize the history of this discovery, known molecular prerequisites of MT nucleation at the Golgi and unique functions of Golgi-derived MTs.

PMID:
23821162
PMCID:
PMC3748218
DOI:
10.1007/s00418-013-1119-4
[Indexed for MEDLINE]
Free PMC Article

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