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Development. 2013 Jul;140(14):2857-66. doi: 10.1242/dev.095927.

Oct transcription factors in development and stem cells: insights and mechanisms.

Author information

1
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. dean.tantin@path.utah.edu

Abstract

The POU domain family of transcription factors regulates developmental processes ranging from specification of the early embryo to terminal differentiation. About half of these factors display substantial affinity for an 8 bp DNA site termed the octamer motif, and are hence known as Oct proteins. Oct4 (Pou5f1) is a well-known Oct factor, but there are other Oct proteins with varied and essential roles in development. This Primer outlines our current understanding of Oct proteins and the regulatory mechanisms that govern their role in developmental processes and concludes with the assertion that more investigation into their developmental functions is needed.

KEYWORDS:

Oct proteins; POU domain; Stem cells

PMID:
23821033
PMCID:
PMC3699277
DOI:
10.1242/dev.095927
[Indexed for MEDLINE]
Free PMC Article

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