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Acta Paediatr. 2013 Oct;102(10):e439-42. doi: 10.1111/apa.12339. Epub 2013 Aug 5.

Perinatal systemic inflammatory responses of growth-restricted preterm newborns.

Author information

1
Department of Obstetrics and Gynecology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. tmcelrath@partners.org

Abstract

AIM:

To compare the early post-natal pattern of systemic inflammation in growth-restricted infants born before the 28th week of gestation to that of appropriately grown peers.

METHODS:

We measured the concentrations of 25 inflammation-related proteins in blood spots collected from 939 newborns during the first 2 post-natal weeks. We calculated the odds ratios (99% confidence intervals) that concentrations would be in the highest quartile.

RESULTS:

Severely growth-restricted infants (birth weight Z-score <-2) were not at increased risk of systemic inflammation shortly after birth. On post-natal day 14, however, they were significantly more likely than their peers to have a CRP, IL-1β, IL-6, TNF-α, IL-8, MCP-4, ICAM-1, ICAM-3, E-SEL, MMP-9, VEGF-R2 and/or IGFBP-1 concentration in the highest quartile. These increased risks could not be attributed to delivery indication, bacteremia or duration of ventilation.

CONCLUSION:

Growth-restricted preterm newborns appear to be at increased risk of elevated concentrations of inflammation-associated proteins by post-natal day 14.

KEYWORDS:

Growth-restricted; IUGR; Inflammation; Neonate; Preterm

PMID:
23819682
PMCID:
PMC3773878
DOI:
10.1111/apa.12339
[Indexed for MEDLINE]
Free PMC Article

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