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Nat Neurosci. 2013 Aug;16(8):1068-76. doi: 10.1038/nn.3446. Epub 2013 Jun 30.

Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.

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1
Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, USA. cpfeffer10@gmail.com

Abstract

Cortical inhibitory neurons contact each other to form a network of inhibitory synaptic connections. Our knowledge of the connectivity pattern underlying this inhibitory network is, however, still incomplete. Here we describe a simple and complementary interaction scheme between three large, molecularly distinct interneuron populations in mouse visual cortex: parvalbumin-expressing interneurons strongly inhibit one another but provide little inhibition to other populations. In contrast, somatostatin-expressing interneurons avoid inhibiting one another yet strongly inhibit all other populations. Finally, vasoactive intestinal peptide-expressing interneurons preferentially inhibit somatostatin-expressing interneurons. This scheme occurs in supragranular and infragranular layers, suggesting that inhibitory networks operate similarly at the input and output of the visual cortex. Thus, as the specificity of connections between excitatory neurons forms the basis for the cortical canonical circuit, the scheme described here outlines a standard connectivity pattern among cortical inhibitory neurons.

PMID:
23817549
PMCID:
PMC3729586
DOI:
10.1038/nn.3446
[Indexed for MEDLINE]
Free PMC Article
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