Format

Send to

Choose Destination
See comment in PubMed Commons below
Malays J Pathol. 2013 Jun;35(1):33-43.

SNP array technology: an array of hope in breast cancer research.

Author information

1
School of Medicine and Health Sciences, Monash University Sunway Campus, Selangor Darul Ehsan, Malaysia.

Erratum in

  • Malays J Pathol. 2013 Dec;35(2):191.

Abstract

Breast cancer is the most common malignancy in women worldwide. The incidence of breast cancer in Malaysia is lower compared to international statistics, with peak occurrence in the age group between 50 to 59 years of age and mortality rates of 18.6%. Despite current diagnostic and prognostic methods, the outcome for individual subjects remain poor. This is in part due to breast cancers' wide genetic heterogeneity. Various platforms for genetics studies are now employed to determine the identity of these genetic abnormalities, including microarray methods like high density single-nucleotide-polymorphism (SNP) oligonucleotide arrays which combine the power of chromosomal comparative genomic hybridization (cCGH) and loss of heterozygosity (LOH) in the offering of higher-resolution mappings. These platforms and their applications in highlighting the genomic alteration frameworks manifested in breast carcinoma will be discussed.

PMID:
23817393
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for College of Pathologists, Academy of Medicine of Malaysia
    Loading ...
    Support Center