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Antimicrob Agents Chemother. 2013 Sep;57(9):4575-7. doi: 10.1128/AAC.00605-13. Epub 2013 Jul 1.

Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics.

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1
College of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, China.

Abstract

The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.

PMID:
23817373
PMCID:
PMC3754308
DOI:
10.1128/AAC.00605-13
[Indexed for MEDLINE]
Free PMC Article
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