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Nephrol Dial Transplant. 2013 Oct;28(10):2432-8. doi: 10.1093/ndt/gft071. Epub 2013 Jun 30.

Animal models of chronic kidney disease: useful but not perfect.

Author information

1
Department of Nephrology, The Royal Melbourne Hospital and Department of Medicine, University of Melbourne, Melbourne, Vic, Australia.

Abstract

Animal models of chronic kidney disease (CKD) approximate the human condition and are keys to understanding its pathogenesis and to developing rational treatment strategies. The ethical use of animals requires a detailed understanding of the strengths and limitations of each species and the disease model, and the way in which findings can be translated from animals to humans. While not perfect, the careful use of animal experiments offers the opportunity to examine individual mechanisms in an accelerated time frame.

KEYWORDS:

animal models; chronic kidney disease

PMID:
23817139
DOI:
10.1093/ndt/gft071
[Indexed for MEDLINE]

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