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Clin Transplant. 2013 Jul-Aug;27(4):567-70. doi: 10.1111/ctr.12166. Epub 2013 Jul 2.

Induction therapy in adult intestinal transplantation: reduced incidence of rejection with "2-dose" alemtuzumab protocol.

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1
Liver and Multiorgan Transplant Center, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Abstract

The incidence of early rejection after intestinal transplantation correlates with heightened risk of graft loss and mortality. Many different induction or pre-conditioning protocols have been reported in the last 10 yr to improve outcomes; however, sepsis remains prevalent and diminishes long-term results. We recently began a "2-dose" alemtuzumab trial protocol - 15 mg at day 0 and 15 mg repeated on day 7 - with the hope of reducing our infection rate. We compared three different protocols used at our institution (daclizumab, conventional "4-dose" alemtuzumab, and "2-dose" alemtuzumab). There was a significantly lower rate of early rejection with the "2-dose" alemtuzumab protocol in our study group of mainly (88%) intestinal grafts without accompanying liver engraftment with its protective immunologic effect. Sepsis remained low. Longer follow-up will be required to evaluate the effects of this new protocol on longer-term outcomes.

KEYWORDS:

acute cellular rejection; alemtuzumab; induction

PMID:
23815302
DOI:
10.1111/ctr.12166
[Indexed for MEDLINE]
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