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J Am Chem Soc. 2013 Jul 17;135(28):10278-81. doi: 10.1021/ja404677c. Epub 2013 Jul 9.

Controlling self-assembly of a peptide-based material via metal-ion induced registry shift.

Author information

1
Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.

Abstract

Peptide TZ1C2 can populate two distinct orientations: a staggered (out-of-register) fibril and an aligned (in-register) coiled-coil trimer. The coordination of two cadmium ions induces a registry shift that results in a reversible transition between these structural forms. This process recapitulates the self-assembly mechanism of native protein fibrils in which a ligand binding event gates a reversible conformational transition between alternate forms of a folded peptide structure.

PMID:
23815081
PMCID:
PMC3786573
DOI:
10.1021/ja404677c
[Indexed for MEDLINE]
Free PMC Article

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