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Dent Res J (Isfahan). 2012 Dec;9(Suppl 2):S192-6. doi: 10.4103/1735-3327.109752.

Picibanil (OK-432) in the treatment of head and neck lymphangiomas in children.

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Department of Medical-Surgical Sciences of Communication and Behaviour, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy.



Picibanil (OK-432) is a lyophilized mixture of group A Streptococcus pyogenes with antineoplastic activity. Because of its capacity to produce a selective fibrosis of lymphangiomas (LMs), it has been approved by Japanese administration in 1995 for the treatment of LMs.


We treated 15 children (age range: 6-60 months) affected by head and neck macrocystic LMs with intracystic injections (single dose of 0.2 mL) of Picibanil (1-3 injections).


Complete disappearance of the lesion was noticed in eight (53.33%) cases, a marked (>50%) reduction of LMs was found five (33.33%) cases, while a moderate (<50%) response was recorded in two (13.33%) cases. Picibanil side effects included fever, local inflammation, and transitory increase of blood platelets' concentration; a single case of anemia was resolved with concentrated red blood cells transfusion.


Intracystic injection of Picibanil is an effective and safe treatment for macrocystic LMs in pediatric patients and may represent the treatment of choice in such cases, especially where surgical excision is associated with the risk of functional/cosmetic side effects.


Children; lymphangiomas; pediatric age; picibanil (OK-432)

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