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J Surg Oncol. 2013 Aug;108(2):121-5. doi: 10.1002/jso.23315. Epub 2013 Jun 29.

MicroRNA-203 down-regulation is associated with unfavorable prognosis in human glioma.

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1
Department of Neurosurgery, Chongqing Red Cross Hospital, Chongqing City, China.

Abstract

BACKGROUND AND OBJECTIVES:

MicroRNA-203 (miR-203) serves as a tumor suppressor or a tumor promoter in different human malignancies. However, its involvement in human gliomas is still unclear. The aim of this study was to investigate the clinical significance of miR-203 expression in gliomas.

METHODS:

Real-time quantitative PCR was employed to measure the expression level of miR-203 in clinical glioma tissues.

RESULTS:

The expression of miR-203 was reduced in high WHO grade glioma tissues compared with that in low WHO grade and normal brain tissues, and decreased with ascending tumor WHO grades (P < 0.001). The reduced miR-203 expression in gliomas was significantly associated with higher WHO grade (P < 0.001), lower KPS score (P = 0.008) and poorer disease-specific survival of patients (P = 0.001). More importantly, subgroup analyses according to tumor WHO grade revealed that the disease-specific survival of patients with low miR-203 expression in high WHO grades (III-IV) subgroup was significantly shorter than those with high miR-203 expression (P < 0.001), but no significant difference was found for patients in WHO grades I-II subgroup (P = 0.08).

CONCLUSION:

Our data validate an important clinical significance of miR-203 in gliomas, and reveal that it might be an intrinsic regulator of tumor progression and a potential prognostic factor for this dismal disease.

KEYWORDS:

glioma; microRNA-203; prognosis; real-time quantitative RT-PCR assay

PMID:
23813496
DOI:
10.1002/jso.23315
[Indexed for MEDLINE]
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