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J Invest Dermatol. 2013 Nov;133(11):2509-2513. doi: 10.1038/jid.2013.238. Epub 2013 Jun 27.

The Cinderella effect: searching for the best fit between mouse models and human diseases.

Author information

1
The Jackson Laboratory, Bar Harbor, Maine, USA. Electronic address: john.sundberg@jax.org.
2
The Jackson Laboratory, Bar Harbor, Maine, USA.
3
The Jackson Laboratory, Bar Harbor, Maine, USA; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.

Abstract

A recent publication questions the suitability of mice as a model for the human inflammatory response and has fueled the continuing debate about the suitability of mice as models for human disease. We discuss recent advances in disease modeling using mice, and the genetic factors that need to be considered when trying to recapitulate aspects of human disease. Failure to appreciate the important differences between human and mouse biology and genetics underlying attempts to generate faithful models frequently leads to poor outcomes. Closely coordinated human and model organism studies are essential to provide traction for translational research.

PMID:
23812235
DOI:
10.1038/jid.2013.238
[Indexed for MEDLINE]
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