Send to

Choose Destination
Coron Artery Dis. 2013 Sep;24(6):501-8. doi: 10.1097/MCA.0b013e3283639eb3.

Coronary calcifications and plaque characteristics in patients with end-stage renal disease: a computed tomographic study.

Author information

Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA.



We examined the association between coronary artery calcifications, atherosclerotic burden, and plaque morphology in end-stage renal disease (ESRD) and non-ESRD patients undergoing 64-slice multidetector coronary computed tomographic angiography.


The prevalence, extent, and severity of coronary atherosclerosis, calcium burden, and plaque morphology were determined in ESRD patients (n=48), and calcium score-matched (n=39) and unmatched non-ESRD controls (n=29) undergoing computed tomographic angiography using dedicated plaque imaging software.


ESRD was associated with a higher prevalence of calcified plaques (55.9% vs. 38.3 and 26.9% in the non-ESRD groups, P=0.005) and higher plaque calcium content (43.7 vs. 34.5% and 33.9%; P=0.003). Nonetheless, the calcium score correlated well with plaque burden (r=0.403 in ESRD vs. r=0.433 in non-ESRD, P<0.001 for both), and the diagnostic association between the calcium score and atherosclerotic lesions was good irrespective of ESRD (area under the curve 0.771 vs. 0.804; P=0.574).


ESRD is associated with diffuse atherosclerosis and calcific plaque morphology. Nonetheless, the association between the calcium score and atherosclerotic burden is not affected by the presence of ESRD.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center