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Eur J Pharmacol. 2013 Sep 5;715(1-3):72-5. doi: 10.1016/j.ejphar.2013.06.016. Epub 2013 Jun 25.

Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis.

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Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.


Endometriosis is one of the most frequent gynecological diseases. In addition to their side effects, available medical therapies may decrease fertility. Current understanding of endometriosis focuses on the role of the immune system in its pathophysiology. Recent research shed light on the immunomodulatory effect of vitamin D3. Thus, this study was designed to study the effect of vitamin D3 on regression of endometriotic implants in a rat surgical model. Vitamin D3 reduced cyst cross sectional area by 48.8%. Histologically, vitamin D treatment produced fibrosis as well as apoptosis in the stroma. The results of the present study suggest that vitamin D3 administration may have a beneficial effect in treating endometriosis.


Cholecalciferol; Endometriosis; Rat surgical model; Vitamin D(3)

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